Periaqueductal grey metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities and thermal nociception

نویسندگان

  • Ida Marabese
  • Francesca Rossi
  • Enza Palazzo
  • Vito de Novellis
  • Katarzyna Starowicz
  • Luigia Cristino
  • Daniela Vita
  • Luisa Gatta
  • Francesca Guida
  • Vincenzo Di Marzo
  • Francesco Rossi
  • Sabatino Maione
چکیده

1 Department of Experimental MedicineSection of Pharmacology "L. Donatelli"Faculty of Medicine and Surgery Second University of Naples, Via Costantinopoli, 16 80138 Naples – Italy. 2 Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli (Naples)Italy 3 Endocannabinoid Research Group, Institute of Cybernetics “E. Caianiello”, Consiglio Nazionale delle Ricerche, Pozzuoli (Naples)Italy *Corresponding author. Tel. +39-81-5667650; Fax. +39-81-5667503; Email [email protected] Page 1 of 53 Articles in PresS. J Neurophysiol (May 16, 2007). doi:10.1152/jn.00356.2007

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Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.

The current study has investigated the involvement of periaqueductal gray (PAG) metabotropic glutamate subtype 7 and 8 receptors (mGluR(7) and mGluR(8)) in modulating rostral ventromedial medulla (RVM) ongoing and tail flick-related on and off cell activities. Our study has also investigated the role of PAG mGluR(7) on thermoceptive threshold and PAG glutamate and GABA release. Intra-ventrolate...

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Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions.

The present study investigated the role of metabotropic glutamate receptor subtype 8 (mGluR8) in the dorsal striatum (DS) in modulating thermonociception and rostral ventromedial medulla (RVM) ON and OFF cell activities in conditions of neuropathic pain induced by spared nerve injury (SNI) of the sciatic nerve in rats. The role of DS mGluR8 on mechanical allodynia was also investigated. Intra-D...

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NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

BACKGROUND Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 agonist, have an analgesia-like effect in rat models of inflammatory and neuropathic pain. The goal of this study was to begin defining locations within t...

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تاریخ انتشار 2007